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A PET-based Treatment Planning System to evaluate the Influence of the Heterogeneous Boron Distribution in Boron Neutron Capture Therapy (BNCT)

Boron Neutron Capture Therapy (BNCT) is based on two important issues: a neutron flux characterized by a suitable spectrum and a B10 carrier able to locate in the proximity to the tumour cells. The knowledge of the precise localization of the boron atoms is fundamental during the treatment planning. Nowadays, Positron Emission Tomography (PET) is able to provide this in vivo information. The idea to couple the Treatment Planning System (TPS) to the information on the real boron distribution in the patient is the main added value of the PET-based TPS methodology, in comparison to the standard TPS, which assumes a uniform boron distribution, absolutely far from the reality.
A new TPS, based on the Monte Carlo technique, has been developed in order to demonstrate the feasibility of this advanced methodology and to initiate a promising branch in the BNCT research.
The validation of the new TPS, called BDTPS (Boron Distribution Treatment Planning System), has been conducted comparing the main BNCT parameters (thermal flux, boron dose, etc.) as measured during the irradiation of a special heterogeneous boron phantom (HEBOM), ad hoc designed, as calculated by the BDTPS and by the standard TPS, SERA. Major SERA errors have been found especially in the calculation of the boron dose, which is the most important parameter in BNCT. For example, the patient irradiation time is determined on the grounds of this value. Therefore, the best knowledge of the boron dose during the treatment planning is a crucial issue in view of a proper BNCT protocol.
Hopefully, this study is the starting point for future improvements in the PET-based TPS research and will be followed by similar works, with the aim to confirm that PET-based TPS methodology represents the next frontier in the BNCT applications. A TPS able to respond properly to the heterogeneity of the boron distribution is the key for successful Boron Neutron Capture Therapy.

Mostra/Nascondi contenuto.
PREVIEW This work is the product of a joint collaboration between the University of Pisa (Dipartimento di Ingegneria Meccanica, Nucleare e della Produzione) and the Joint Research Centre of the European Commission (Institute for Energy, Petten). The main goal was the invention, development, test and validation of a treatment planning system based on the boron distribution data acquired through Positron Emission Tomography (PET) scanning. The main added value of this effort is the demonstration of the feasibility of PET-based BNCT as a new methodology for describing the complex boron heterogeneity and its correlation with the treatment planning results. After an historical introduction (Chapter 1) on the treatment planning systems up to now used in the Boron Neutron Capture Therapy community and on the new boron in vivo detection methods (PET, MRI, etc.), the Monte Carlo technique applied to the particle transport calculation is described in Chapter 2. A general review related to the treatment planning systems used in BNCT and their role in the protocol, from the proper positioning of the patient’s organ to the evaluation of the main organs at risk, are included in Chapter 3. Here, the principal features of BNCT_rtpe, SERA and NCTPlan are presented. In order to better explain the role of the present work, an historical overview could be helpful. This is the reason of the Chapter 4, where a flashback on the previous work, CARONTE, performed by the author is given. Also a review of the most important in vivo boron detection techniques is reported. Among these technique, PET is up to now the most advanced in relation to the spatial resolution. Moreover, this technique provides the boron distribution data in a format, which can be compared with CT data. This gives the possibility to combine the PET data to the anatomical CT data into an ad hoc treatment planning system. This strategic importance required a full explanation of PET main concepts in Chapter 5.

Tesi di Dottorato

Dipartimento: Dip. di Ing. Meccanica Nucleare e Produzione

Autore: Giuseppe Giovanni Daquino Contatta »

Composta da 317 pagine.


Questa tesi ha raggiunto 886 click dal 12/10/2005.

Disponibile in PDF, la consultazione è esclusivamente in formato digitale.