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In silico simulation of cell proliferation and movement

In this work, a system is described for simulating experiments on eukaryotic cell cultures, conducted in dynamic time-lapse microscopy. The system is based on basic entities such as cell, plate and experiment and may be accessed through a web interface.
The cell object has, among its properties, the ability to divide, die, undergo volumetric growth and move; the plate object has the function to manage a certain number of cells and to monitor them, both for position and status. The experiment object manages the two objects, monitors the time and collects the results that are shown in the form of tables.
Example experiments were performed to analyze growth of different cell populations, evaluate cell populations that have different rates of mortality and cell populations, simulate wound healing experiments and populations including drug-resistant cells.

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1. ABSTRACT In this work, a system is described for simulating experiments on eukaryotic cell cultures, conducted in dynamic time-lapse microscopy. The system is based on basic entities such as cell, plate and experiment and may be accessed through a web interface. The cell object has, among its properties, the ability to divide, die, undergo volumetric growth and move; the plate object has the function to manage a certain number of cells and to monitor them, both for position and status. The experiment object manages the two objects, monitors the time and collects the results that are shown in the form of tables. Example experiments were performed to analyze growth of different cell populations, evaluate cell populations that have different rates of mortality and cell populations, simulate wound healing experiments and populations including drug-resistant cells. 2

Tesi di Laurea Magistrale

Facoltà: Scienze Matematiche, Fisiche e Naturali

Autore: Teresa Rosa Galise Contatta »

Composta da 34 pagine.

 

Questa tesi ha raggiunto 33 click dal 03/05/2018.

Disponibile in PDF, la consultazione è esclusivamente in formato digitale.