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Comparison of [123I]Epidepride & [123I]IBZM SPECT tracers for Brain Dopamine D2 Receptor Imaging using Micro SPECT

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  12   synthesised for further study of this system in extra striatal regions like in cortex. Due to their high affinity, these ligands provide particular challenges with regard to quantification of binding in the human brain in vivo. Radioligands used in this thesis ([ 123 I]IBZM and [ 123 I]Epidepride) are used to quantify DA receptors (D2/D3) are substituted benzamides (DeLong M 2010). Dopamine is a monoamine neurotransmitter, which is produced in the brain and exerts various functions, especially reward driven learning and complex motor functions. Caudate and Putamen are two regions of grey matter, mid brain regions, which are separated by skins of white matter combinly, known as striatum (C+P = S). This is where dopamine exerts its effects and the major output and input is to the deep brain regions called basal ganglion. This system plays a key role in movement and receives signals from cerebral cortex mainly prefrontal, intra laminar nuclei, substantia nigra, amygdala, hippocampus, midbrain raphe nuclei and sensorimotor cortex. Interference in this dopamine action are at the root of various brain abnormalities such as schizophrenia and addiction. These are caused by elevated levels of dopamine (Breier A 1998) (Doran AR 1987) Parkinson's, Attention deficit hyperactivity disorder (ADHD), (Berridge CW 2011, Wu J 2012) and restless leg syndrome (Paulus W 2006) are considered to be associated with decreased dopamine levels. The cells responsible in producing dopamine neurotransmitter are localized in substantia nigra, Ventral Tegmental Area (VTA), posterior hypothalamus, Arcuate nucleus (medio basal hypothalamus) and Zona incerta (grey matter sub thalamus), which then projects into striatum. Outside the striatum it is believed to be produced in proximal tubule cells of the kidney where the dopamine functions are at localized level (Ben-Jonathan N 2001, Paulus W 2006, Bjo ̈rklund A 2007, Robbins TW 2009, DeLong M 2010). IBZM binding to striatal regions can be visualized on figure 2.

Anteprima della Tesi di Manideep Gupta

Anteprima della tesi: Comparison of [123I]Epidepride & [123I]IBZM SPECT tracers for Brain Dopamine D2 Receptor Imaging using Micro SPECT, Pagina 6

International thesis/dissertation

Autore: Manideep Gupta Contatta »

Composta da 89 pagine.

 

Questa tesi ha raggiunto 4 click dal 08/05/2014.

Disponibile in PDF, la consultazione è esclusivamente in formato digitale.